| Paw Paw selectively targets specific cells to enhance the overall health of the body. Paw Paw twigs contains acetogenins-active compounds that modulate the production of ATP in the mitochondria of specific cells, which affects the viability of specific cells and the growth of blood vessels that nourish them. A recent clinical study with over 100 participants showed that the paw paw extract, containing a mixture of acetogenins, supports the body's normal cells during times of cellular stress. Paw Paw is a valuable tool in strengthening and supporting the immune system. This patent-pending product is the only standardized acetogenin product available to regulate specific cells. Each capsule contains 12.5 mg of standardized paw paw twig extract. Take 1 capsule with food four times daily. Do not take with Co-Q10 or SOD; do not take with KC-X or other thyroid-stimulating products. Avoid taking a large amount of antioxidant products in combination with Paw Paw. Do not exceed the number of recommended servings. Only those who desire to target specific cells should take this product on a regular/daily basis. Stock No. 511-3 (120)
Paw Paw extract contains acetogenins-active compounds that modulate the production of ATP** in mitochondria of cancer cells. This reduces the growth of blood vessels that nourish cancer cells. It also inhibits the growth of MDR (multiple drug resistance) cells. No other alternative or conventional cancer treatment (except treatments from trees similar to Paw Paw) has shown any effectiveness against MDR cells.
Paw Paw is a cousin of the graviola, guanabana, and soursop trees. However, the acetogenins extracted from Paw Paw are more active against cancer than those extracted from these other sources.
Paw Paw seems to work in a very similar manner to Cancell. It seems effective against viruses and reduces the side effects of chemo.
Multiple Drug Resistant Cells
Most tumors contain a small percentage, approximately 2%, of multiple drug-resistant cells (MDR cells). Chemo is not effective against these cells. After the first round of chemo, if the chemo is effective, all of the cells that are not MDR, are destroyed. Since this accounts for the vast majority of the tumor mass, the tumor will appear to be effectively destroyed. However, the MDR cells remain and start to multiply. Eventually, a new tumor is formed that is entirely MDR. The next time chemo is used, none of the cells will be destroyed because they are all MDR. Paw Paw is the only cancer treatment that has shown effectiveness against MDR cells.
Development
Paw Paw research was performed at Purdue College by Jerry McLaughlin. The majority of the funding (20 years and about 5 million dollars) for this research was provided by NCI. Jerry McLaughlin now works with Nature Sunshine who manufactures Paw Paw twig extract in capsule form.
Pharmacology
Click this link for a 37 page, scientific paper (not for the laymen) on Paw Paw twig extract written in 1999 entitled "Annonaceous Acetogenins: Recent Progress."
Effectiveness
Paw Paw seems to work on all types of cancers. An informal study of 100 cancer patients showed that Paw Paw was effective in half the cases. This is most interesting since Paw Paw seems to work the same way that Cancell works and Cancell has a 50% effectiveness also. However, Paw Paw gets higher marks in the effectiveness because, in the laboratory, it inhibits the growth MDR (multiple drug resistance) cells. No other cancer treatment including chemo has shown any effectiveness against MDR cells. Jerry McLaughlin is in the negotiation process for starting clinical trials in conjunction with Harvard University. However, no formal clinical trials have yet occurred. For more on MDR cells, see the "Multiple Drug Resistant Cells" section above.
Studies
Here a few abstracts from studies conducted at Purdue University where most of the Paw Paw research for the past 30 years was conducted:
ABSTRACT: Cancer Letters 115 (1997) 73-79
The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells
Nicholas H. Oberlies, Vicki L. Croy, Marietta L. Harrison, Jerry L. McLaughlin
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University.
Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms.
ABSTRACT: J. Med. Chem. 1997, 40, 2102-2106
Structure-activity relationships of diverse Annonaceous acetogenins against multidrug-resistant human mammary adenocarcinoma (MCF-7/Adr) cells
Nicholas H. Oberlies, Ching-jer Chang, Jerry L. McLaughlin
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University.
Fourteen structurally diverse Annonaceous acetogenins, representing the three main classes of bis-adjacent, bis-nonadjacent, and single-THF ring(s), were tested for their ability to inhibit the growth of adriamycin-resistant human mammary adenocarcinoma (MCF-7/Adr) cells. This cell line is resistant to treatment with Adriamycin, vincristine, and vinblastine and is, thus, multidrug-resistant (MDR). Among a series of bis-adjacent THF ring acetogenins, those with the stereochemistry of threo-trans-threo-trans-erythro (from C-15 to C-24) were the most potent with as much as 250 times the potency of Adriamycin. A spacing of 13 carbons between the flanking hydroxyl of the THF ring system and the gamma-unsaturated lactone seems to be optimum with a spacing of 11 and 9 carbons being significantly less active. Several single-THF ring compounds were also quite potent, with gigantetrocin A (11) being the most potent compound tested. The acetogenins may, thus, have chemotherapeutic potential, especially with regard to MDR tumors.
Copies of the journal articles mentioned in the story are available from the Purdue News Service, (765) 494-2081.
Quantity of Papers
There have been over 100 scientific papers published on the chemistry and biology of the paw paw compounds.
Paw Paw and Viruses
ATP is a direct and indirect precursor of DNA and RNA. This slows or stops viral reproduction for viruses such as cold sores and shingles.
Conclusiveness of Papers
Almost all but research papers regarding Paw Paw demonstrate significant effectiveness in the laboratory against the usual form of cancer cells and MDR cells.
Standalone Ability
Considering the performance of Paw Paw against MDR cells, it would appear that Paw Paw would stand alone as a cancer treatment very well. However, the manufacture and developer feel that the following supplements would aid Paw Paw:
- Immune Stimulator
- Protease Plus
Ease of Use and Dosage
Paw Paw is easy to use. You only need four capsules, evenly spaced out during the day, and taken with some food.
People who change their eating habits greatly increase the effectiveness of the supplements they take. Consider reading the "General Diet*" subsection of the Home page.
Dosage
Take 1 capsule with food four times a day at even intervals. Do not take any of the following while taking Paw Paw:
- Co-Q10
- Thyroid Support products
- SOD
- 7-Keto
- Antioxidant products such as vitamin A, vitamin C, or vitamin E*
- Sulfhydrazly antioxidants which includes: L-cysteine
N-acetylsteine
Alpha-lipoic acid
Glutathione
* The amount of these vitamins found in fruits and vegetables will not have a serious effect on the performance of Paw Paw.
Do not exceed the number of recommended Paw Paw dosage of four capsules per day. Only those who desire to target specific cells should take this product on a regular/daily basis.
Side Effects
Paw Paw gravitates toward cells that use a lot of energy and cut off their energy supply. Since cancer cells use 10-17 times as much energy as a normal cell, Paw Paw acts on cancer cells. It is the same mechanism that made it so useful as a parasite cleanse and to kill hair lice. It is also the reason that a pregnant woman should not take it. Paw Paw could see the baby as a high energy user.
If no cancer, parasite, or other high energy users are available, Paw Paw may gravitate towards fast growing cells lining the digestive and intestinal system walls. This is why the manufacturer, Nature's Sunshine, strongly cautions against long term use for non-cancer patients.
Some people with cancer have reported digestion distress such as nausea. For this reason it is recommended to take Paw Paw with food.
Compatibility
The following interfere with Paw Paw:
- Co-Q10
- Thyroid Support products
- SOD
- 7-Keto™
- Antioxidant products such as vitamin A, vitamin C, vitamin E,* or Alpha Lipoic Acid
* The amount of these vitamins found in fruits and vegetables will not have a serious effect on the performance of Paw Paw.
Sulfhydrazly antioxidants were removed from the above list after labrotoby tests verified that they did not interfere with Paw Paw.
Year Available
Paw Paw was made available for purchase by Nature's Sunshine in 2003. Since Paw Paw and graviola are so closely related it should be noted that graviola has been under study and some use since the 1940's.
Questions Asked about Paw Paw
Q: Why should I avoid supplementation with CoQ10 or products to support the thyroid (KC-X)?
A: Taking CoQ10 or thyroid products may decrease the effectiveness of Paw Paw. CoQ10 and thyroid stimulating products like KC-X increase the mitochondrial ATP energy production. Compounds called acetogenins, found in the Paw Paw, act by decreasing this energy production. Taking both products would have a counteractive effect. It is not dangerous to take the products together, but less effective.
Q: Could I separate the time between the time I take CoQ10 (or KC-X) and Paw Paw? For example, could I take CoQ10 in the morning and Paw Paw at night?
A: NSP suggests to avoid those products altogether while taking Paw Paw.
Q: What about antioxidants? Should I avoid those as well?
A:Â When Nature's Sunshine first introduced Paw Paw, we cautioned (based on theoretical considerations) against the concurrent use of antioxidants. Since the launch, NSP has conducted clinical trials on Paw Paw that have shown antioxidants do not interfere with the effectiveness of Paw Paw. In fact, it was found Zambroza had no negative effect on the anticancer activity of Paw Paw and may actually enhance the cytotoxic activity at higher concentrations. It was also found that Zambroza alone has some anticancer activity against the
HCT
-116 cells used in the study.
 Q: What about Target Endurance? Some people say that it stimulates SOD production in the body; is it to be avoided as well?
A: There is no direct support for Target Endurance in affecting SOD levels or function. There shouldn't be any problems with taking this product in combination with Paw Paw.
Q: Can I take Paw Paw with medications?
A: There are no known interactions between Paw Paw and drugs. As mentioned above, thyroid stimulating herbs or drugs may have a counterproductive effect. However, NSP does not recommend stopping any thyroid drugs, unless under a physicians supervision. (Updated!)
Q: What about Synthroid? If we should avoid thyroid-stimulating products while taking Paw Paw, can someone who's on Synthroid take Paw Paw?
A. As long as the individual has a properly functioning thyroid gland, and the thyroid is not over stimulated, that person can take Paw Paw. If the dosage of Synthroid the individual's doctor has put them on is enough to achieve proper thyroid function and balance, we would consider that person to have a normally-functioning thyroid gland (even though it's with the aid of a synthetic hormone), and that person would be able to take Paw Paw.
Those individuals who have a normally-functioning thyroid and choose to take thyroid-stimulating products (for whatever reason) should avoid taking Paw Paw.
Q: What are some complementary products?
A: Nature's Noni, Immune-stimulating herbs (especially Astragalus), Colostrum and Protease Plus are complementary products to Paw Paw.
Q: Can I continue to take products like E-Tea® and Pau D'Arco?
A: Yes, those products are fine to continue.
Q: Should I take Paw Paw as a preventative?
A: No. It is not intended for daily supplementation.
Q: Can I take more Paw Paw than the label recommendations (one capsule with food four times daily)?
A: No, NSP does not recommend exceeding label recommendations. Paw paw is known to cause nausea and vomiting when taken in higher doses. It will not work better in higher amounts.
Q: I feel some minor stomach upset occasionally after taking the Paw Paw. Is there anything to help reduce that?
A: Although some people tend to be more sensitive to the product than others, NSP recommends taking the Paw Paw with some food, so as to decrease the incidence of stomach upset. Ginger is also an herb that can be used with Paw Paw. Ginger has been used for more that 2000 years. It has a history of use in reducing occasional stomach upset.
Q: If Paw Paw affects ATP production in cells, won’t it damage my normal cells as well?
A: No, Paw Paw selectively damages abnormal cells. The reason is that abnormal cells require much more ATP to function than normal cells do. The amount of ATP decline in a normal cell that might be induced by Paw Paw is not enough to affect it, whereas the amount of ATP decline in an abnormal cell is enough to make that cell undergo apoptosis (programmed cell death).
Q: Will Paw Paw affect the normally rapidly growing cells in the body (hair follicles, bone marrow, gastrointestinal tract lining) the same way that chemotherapy drugs do?
A: No, the common side effects of chemo such as hair loss, bone marrow depression and gastrointestinal bleeding do not occur with Paw Paw use. Chemo drugs act on an entirely different mechanism than Paw Paw; they actually damage the DNA of all cells, not just abnormal ones. This effect is more noticeable with the body's normally fast-growing cells, and that’s why people get hair loss, GI bleeding and bone marrow depression with chemo. Paw Paw depresses ATP production in the cells. In abnormally growing cells, this depression is enough to cause those cells to undergo programmed cell death. In the body's normally growing cells (even the faster-growing ones like bone marrow), the decrease in ATP is not enough to cause cell death.
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